基本信息

姓名：彭宜

职称：副教授

电子信箱：pengysky@126.com

办公室：生物工程教研室

个人简介

博士后，硕士研究生导师。美国德州农工大学健康科学中心生物科学技术研究所、美国贝勒医学院分子与细胞生物学系访问学者。主要从事靶向肿瘤的生物材料研发、肿瘤分子免疫学机制的研究并筛选抗肿瘤基因，利用基因工程技术改造溶瘤病毒并构建重组溶瘤病毒，研究基于重组溶瘤病毒的肿瘤疫苗的肿瘤生物治疗作用和分子免疫机理，研究获得国家自然科学基金项目和省部级科研项目资助。发表SCI论文17篇，获得授权专利5项。荣获“中国免疫学会第五届青年学者奖”等学术奖项5项。

科研项目

（1）国家自然科学基金青年基金项目，81703067，转铁蛋白介导重组IP10基因禽 流感病毒特异性抗肿瘤研究，主持

（2）国家自然科学基金地区科学基金项目，81360348，hTERT修饰的禽流感病毒重组异源基因疫苗靶向抗肿瘤研究，主持

（3）广西自然科学基金面上项目，2011GXNSFA018088，H1亚型禽流感病毒HA蛋白单克隆抗体的制备及抗原捕捉ELISA检测方法的建立，主持

主要论文

（1）Huiqin Zhuo^#, Yi Peng^#, Qin Yao^#, Nuo Zhou, Sufang Zhou,Jian He, Yuan Fang, Xi Li, Hongwei Jin, Xiaoling Lu^*, Yongxiang Zhao^*, Tumor Imaging and Interferon-gamma-Inducible Protein-10 Gene Transfer Using a Highly Efficient Transferrin-Conjugated Liposome System in Mice, Clinical Cancer Research, 2013 , 19(15): 4206-4217

（2）Yi Peng, Zhixun Xie^*, Jiabo Liu, Yaoshan Pang, Xianwen Deng, Zhiqin Xie, Liji Xie, Qing Fan, Sisi Luo, Epidemiological surveillance of low pathogenic avian influenza virus (LPAIV) from poultry in Guangxi Province, Southern China, PLos One, 2013, 8(10):e77132

（3）Yi Peng, Zhixun Xie^*, Jiabo Liu, Yaoshan Pang, Xianwen Deng, Zhiqin Xie, Liji Xie, Qing Fan, Jiaxun Feng, Mazhar I Khan^*, Visual detection of H3 subtype avian influenza viruses by reverse transcription loop-mediated isothermal amplification assay, Virology Journal, 2011, 8:337

（4）Yuan Zhou^#,*, Yi Peng^#, Qiqi Mao, Xia Li, Mingwu Chen, Ting Su, Li Tian, Naiquan Mao, Lingzhi Long, Meifang Quan, Fei Liu, Sufang Zhou^*, Yongxiang Zhao^*, Casticin induces caspase-mediated apoptosis via activation of mitochondrial pathway and upregulation of DR5 in human lung cancer cells, Asian Pacific Journal of Tropical Medicine, 2013, 5:372-378

（5）Zhixun Xie*,Yi Peng, Sisi Luo, Ying Wang, Jiabo Liu, Yaoshan Pang, Xianwen Deng, Zhiqin Xie, Liji Xie, Qing Fan, Liqiong Teng, Xiuqing Wang*, Development of a Reverse Transcription Loop-Mediated Isothermal Amplification Assay for Visual Detection of Avian Reovirus, Avian Pathology, 2012, 41(3):311-316

（6）Chunhui Lai^#, Xia Yu^#, Yuan Xie^#,Jian He, Yi Peng, Sufang Zhou, Xiaoxun Xie, Guorong Luo, Nuo Zhou, Yongxiang Zhao^*, Xiaoling Lu^*, Anti-Tumor Immune Response of Folate-Conjugated Chitosan Nanoparticles Containing the IP-10 Gene in Mice with Hepatocellular Carcinoma, Journal of Biomedical Nanote -chnology, 2014, 10(12): 3576-3589

（7）Danni Ren^#, Jinxiao Chen^#, Zhi Li^#, Hongwei Yan, Yan Yin, Da Wo, Jiankang Zhang, Luoquan Ao, Bo Chen, Takashi K. Ito, Yihan Chen, Zhongmin Liu, Yongyong Li, Jianhua Yang, Xiaoling Lu, Yi Peng, Linghui Pan, Yongxiang Zhao^*, Shangfeng Liu^*, Weidong Zhu^*, LRP5/6 directly bind to Frizzled and prev -ent Frizzled-regulated tumor metastasis, Nature Communications, 2015,6: 6906

（8）Huiwen Song^*, Jun Pu, Lin Wang, Lihua Wu, Jianmin Xiao, Qigong Liu, Jun Chen, Min Zhang, Yang Liu, Mingke Ni, Jinggang Mo, Yunliang Zheng, Deli Wan, XiongJiu Cai, Yaping Cao, Weiyi Xiao, Lei Ye, Enyuan Tu, Zhihai Lin,Jianxin Wen, Xiaoling Lu, Jian He, Yi Peng, Jing Su, Heng Zhang, YongxiangZhao^*, Meihua Lin^*, Zhiyong Zhang^*, ATG16L1 phosphorylation is oppositely regulated by CSNK2/casein kinase 2 and PPP1/protein phosphatase 1 which determines the fate of cardiomyocytes during hypoxia/reoxygenation, Autophagy, 2015,11 (8):1308-1325

（9）Chao Qu, De He, Xiaoling Lu, Lihua Dong, Yuekun Zhu, QinZhao, Xin Jiang, Pengyu Chang, Xinping Jiang, Lizhe Wang, Yuyu Zhang, Lirong Bi, Jian He, Yi Peng, Jing Su, Heng Zhang, He Huang, Yan Li, Sufang Zhou, Yaqin Qu, Yongxiang Zhao, Zhiyong Zhang.Salt-inducible Kinase (SIK1) regulates HCC progression and WNT/β-catenin activation, Journal of Hepatology, 2016; 64(5): 1076-1089

（10）Kimberly R. Holloway^#, Vidya C. Sinha^#, Wen Bu, Michael Toneff, Jie Dong, Yi Peng, Yi Li^*, Targeting Oncogenes into a Defined Subset of Mammary Cells Demonstrates That the Initiating Oncogenic Mutation Defines the Resulting Tumor Phenotype,International Journal of Biological Sciences, 2016, 12(4):381-388

（11）Yingying Huang,Qiqi Mao,Jian He,Jing Su,Yi Peng,Wei Liang,Zixi Hu,Sufang Zhou,Xiaoling Lu,Yongxiang Zhao*,Fusions of Tumor-derived Endothelial Cells with Dendritic Cells Induces Antitumor Immunity, Scientific Reports, 2017,7:46544. doi: 10.1038/srep46544

（12）Tao Zhang, Yihua Chen, Jingjie Li, Feifei Yang, Haigang Wu, Fujun Dai, Meichun Hu, Xiaoling Lu, Yi Peng, Mingyao Liu^*,Yongxiang Zhao^*, Zhengfang Yi^*, Antitumor Action of a Novel Histone Deacetylase Inhibitor, YF479, in Breast Cancer, Neoplasia, 2014, 16(8):665-677

（13）Qiqi Mao^#, Xianing Huang^#, Jian He^#, Wei Liang, Yi Peng, Jing Su, Yingying Huang, Zixi Hu, Xiaoling Lu^*, Yongxiang Zhao^*, A novel method for endothelial cell isolation, Oncology Reports, 2016, 35(3):1652-1656

（14）Yanmin Dong,Tao Zhang, Jingjie Li, Huayun Deng, Yajuan Song, Dong Zhai, Yi Peng, Xiaoling Lu, Mingyao Liu, Yongxiang Zhao^*, Zhengfang Yi^*, Oridonin inhibits tumor growth and metastasis through anti-angiogenesis by blocking the Notch signaling, PLos One, 2014, 9(12):e113830

（15）Mongkhoune Sodaly, Yuan Xie, Yuqing Wang, Yue Chen, Nuo Zhou, Yi Peng,Jian He, Xia Yu, Sufang Zhou, Guorong Luo, Yongxiang Zhao^*, Xiaoling Lu^*, A constructed HLA-A2-restricted pMAGE-AI(278-286) tetramer detects specific cytotoxic T lymphocytes in tumour tissues in situ, Journal of International Medical Research, 2013, 41(6):1811-1824

（16）Xia Yu^#, Jian he^#, Sodaly Mongkhoune^#, Yi Peng, Yuan Xie, Jing Su, Sufang Zhou, Xiaoxun Xie, Guorong Luo, Yuan Fang, Xi Li, Nuo Zhou^*, Yongxiang Zhao^*, Xiaoling Lu^*, Artificial antigen-presenting cells plus IL-15 and IL-21 efficiently induce melanoma-specific cytotoxic CD8⁺CD28⁺T lymphocyte responses, Asian Pacific Journal of Tropical Medicine, 2013, 6(6):467-472

（17）Xiaowen Liu#,Xiaoquan Wang,Shuang Wu,Shunlin Hu,Yi Peng,Feng Xue,Xiufan Liu*, Surveillance for avirulent Newcastle disease viruses in domestic ducks (Anas platyrhynchos and Cairina moschata) at live bird markets in Eastern China and characterization of the viruses isolated, Avian Pathology, 2009, 38(5):377-391

近期授权专利

（1）彭宜，彭霞。溶瘤异源重组新城疫病毒及其制备方法与应用，CN 105779397 B，2019.07.19。

主要学术奖励

（1） 彭宜，中国免疫学会第五届青年学者奖，中国免疫学会，2015

（2）Peng Y.（1/9），Genetic Characterization of H9N2 Subtype Field Isolate from Avian Influenza Outbreak in Chinese Francolin，The Houghton Trust/UK，The 8^thInternational AI SymposiumTravel award，2012.