1.基本情况

马文杰，男，汉族，中共党员，甘肃天水人，理学博士。主要从事功能化DNA纳米材料在生物分析、肿瘤诊疗领域的应用研究。参与国家自然科学基金面上项目2项。在Analytical Chemistry期刊上发表科研论文4篇，在Journal of Instrumental Analysis期刊上发表综述1篇。

2.学习及教育

2015.09-2021.12  湖南大学化学专业，博士学位

2011.09-2015.06  河西学院生物工程专业，学士学位

3.工作经历

2022.06-至今     湖南工程学院材料与化工学院，讲师

4.研究方向

DNA纳米探针设计、化学与生物传感、肿瘤成像与治疗

5.科研项目

(1) 国家自然科学基金面上项目，基于介孔二氧化硅纳米材料的低背景级联信号放大电化学传感体系及其RNA肿瘤标志物检测研究（编号21874035），2019/01-2022/12，66万元，在研，参与

(2) 国家自然科学基金面上项目，基于DNA纳米技术的激活式核酸适配体探针构建及其肿瘤活体荧光成像（编号21675046），2017/01-2020/12，65万元，结题，参与

6.代表性论文专著

(1) Wenjie Ma, Huanhuan Sun, Biao Chen, Ruichen Jia, Jin Huang, Hong Cheng, Xiaoxiao He∗, Mingmin Huang*, and Kemin Wang∗. Engineering a facile aptamer “molecule-doctor” with hairpin-contained i-motif enables accurate imaging and killing of cancer cells. Analytical Chemistry, 2021, 93(43): 14552-14559.

(2) Wenjie Ma, Biao Chen, Ruichen Jia, Huanhuan Sun, Jin Huang, Hong Cheng, Huizhen Wang, Xiaoxiao He* and Kemin Wang*. In situ hand-in-hand DNA tile assembly: A pH-driven and aptamer-targeted DNA nanostructure for TK1 mRNA visualization and synergetic killing of cancer cells. Analytical Chemistry, 2021, 93(30):10511-10518.

(3) Wenjie Ma, Biao Chen, Shanzi Zou, Ruichen Jia, Hong Cheng, Jin Huang, Huizhen Wang, Xiaoxiao He* and Kemin Wang*. I-motif-based in situ bipedal hybridization chain reaction for specific activatable imaging and enhanced delivery of antisense oligonucleotides. Analytical Chemistry, 2019, 91(19): 12538-12545.

(4) Wenjie Ma, Lv’an Yan, Xiaoxiao He*, Taiping Qing, Yanli Lei, Zhenzhen Qiao, Dinggeng He, Kaihang Huang and Kemin Wang*. Hairpin-contained i-motif based fluorescent ratiometric probe for high-resolution and sensitive response of small pH variations. Analytical Chemistry, 2018, 90(3): 1889-1896.

(5) Wenjie Ma, Jin Huang, Hong Cheng, Ruichen Jia, Biao Chen, Huanhuan Sun, Yuchen Wu, Xiaoxiao He∗,and Kemin Wang∗. I-motif-based nanosystems for biomedical applications: pH imaging，drugs controlled release and tumor theranostics. Journal of Instrumental Analysis, 2022, 41(4): 486-497.